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KMID : 0620920080400050550
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Experimental & Molecular Medicine
2008 Volume.40 No. 5 p.550 ~ p.557
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Spatiotemporal regulation of fibroblast growth factor signal blocking for endoderm formation in Xenopus laevis
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Cha Sang-wook
Kim Dong-Sun
Park Mae-Ja
Chae Jeong-Pil
Park Kwon-Moo
Lee Jong-Woo
Hwang Yoo-seok
Cho Hee-Jung
Bae Yong-Chul
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Abstract
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We have previously shown that the inhibition of fibroblast growth factor (FGF) signaling induced endodermal gene expression in the animal cap and caused the expansion of the endodermal mass in Xenopus embryos. However, we still do not know whether or not the alteration of FGF signaling controls embryonic cell fate, or when FGF signal blocking is required for endoderm formation in Xenopus. Here, we show that FGF signal blocking in embryonic cells causes their descendants to move into the endodermal region and to express endodermal genes. It is also interesting that blocking FGF signaling between fertilization and embryonic stage 10.5 promotes endoderm formation, but persistent FGF signaling blocking after stage 10.5 restricts endoderm formation and differentiation.
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KEYWORD
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embryonic development, endoderm, fibroblast growth factors, SU 5402, Xenopus
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